Adamax
peptide · headlineResearch use onlyUpregulates BDNF (brain-derived neurotrophic factor) expression in hippocampus and cortex
Overview
Adamax is a next-generation nootropic peptide and enhanced Semax analog featuring N-terminal acetylation and C-terminal adamantane modification for superior stability and blood-brain barrier penetration. It upregulates BDNF, enhances TrkB receptor sensitivity, modulates monoamines, and provides neuroprotection against oxidative stress and excitotoxicity.
How it works
- Upregulates BDNF (brain-derived neurotrophic factor) expression in hippocampus and cortex
- Enhances TrkB receptor sensitivity for improved neurotrophin signaling
- Modulates monoamine neurotransmitter levels (dopamine, norepinephrine, serotonin)
- Activates neuroprotective pathways reducing oxidative stress
- Stabilizes microtubules through ADNP-derived mechanisms
- Reduces excitotoxicity through neuromodulation
Dosing
Standard dose: 300-1000 mcg daily via intranasal spray or injection, administered daily with gradual titration.
Caution Start with the lowest recommended dose (300 mcg) to assess individual tolerance. Adamax can cause insomnia and anxiety in sensitive individuals; avoid dosing after 2 PM. Do not exceed 1000 mcg daily without medical supervision. Limited long-term human safety data exists.
Cycling
- Can be used daily without cycling; however, some users rotate 5 days on / 2 days off to prevent tolerance development. Nasal mucosa health should be monitored during extended use.
- Daily administration recommended without cycling for cognitive support. Some protocols suggest 3 weeks on / 1 week off for tolerance management.
Side effects
- Common
- Nasal irritation or congestion (intranasal administration)
- Mild headache (usually transient)
- Slight insomnia if dosed late in the day
- Warnings
- May cause anxiety or overstimulation at high doses
- Risk of sleep disruption if taken in evening
- Limited long-term human safety data available
- Long Term
- Long-term safety profile unknown in humans
- Extrapolated from Semax clinical experience only
Stacking & combinations
- With
Semax
- Benefit
Additive BDNF and neuroprotective effects; Adamax potentially superior bioavailability
- With
P21
- Benefit
Combined cognitive enhancement and neuroprotection; complementary mechanisms of action
- With
BPC-157
- Benefit
Synergistic neuroprotection and tissue repair; enhanced recovery from neurological stress
Lifestyle support
- Diet
Nutrient-dense diet rich in antioxidants. Adequate hydration.
- Sleep
Adequate sleep (7–9 hours). Stable circadian rhythm. Stress management supports neuroprotective benefits.
- Timing
Avoid late-day dosing to prevent sleep disruption.
- Exercise
Regular aerobic exercise.
Reconstitution calculator
Subcutaneous Injection= 0.06 mL on a U-100 insulin syringe
Assumes a U-100 insulin syringe (100 units = 1 mL). This is a preparation aid, not a protocol · dose and route are the prescriber's decision. Refrigerate at 2-8°C (35.6-46.4°F) after reconstitution with bacteriostatic water. Use within 2-4 weeks. Discard if solution becomes discolored.
Chemistry & PK
Bioavailability
Storage & handling
- Lyophilized
Store at -20°C (-4°F) in a cool, dark place away from light and moisture. Stability of 2+ years when properly stored.
- Reconstituted
Refrigerate at 2-8°C (35.6-46.4°F) after reconstitution with bacteriostatic water. Use within 2-4 weeks. Discard if solution becomes discolored.
Used for
No condition evidence rows yet.
Legal / compounding
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.