Metformin
off-label Rx · medium oversightFDA-approvedAMPK activation; reduced hepatic gluconeogenesis
Overview
Biguanide; first-line for insulin resistance in PCOS and widely used off-label for longevity. Activates AMPK and reduces hepatic gluconeogenesis.
How it works
- AMPK activation
- ↓ hepatic gluconeogenesis
- ↑ insulin sensitivity
Dosing
500–2000 mg/day (extended-release preferred).
Oral1000 mg standardrange ·–2000 mg· daily (ER, with food)
Cycling
- Continuous
Side effects
- Common
- GI upset (dose-related)
- B12 depletion (long-term)
- Warnings
- Rare lactic acidosis (renal impairment)
Verified citations
2 · PubMed-checked- Metformin improves healthspan and lifespan in mice.preclinicalPMID 23900241
- Evidence That Metformin Is a Putative Anti-Aging Drug.reviewPMID 34421827
Reconstitution
Not applicable · this compound is oral. No vial reconstitution needed.
Used for
Legal / compounding
FDA-approved
FDAApproved
Legal status is a hard gate: non-compoundable or delisted agents cannot be filled and are blocked from protocol export. Keep 503A status current.